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How to Live Younger, Longer

December 22, 2025
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The Longevity Blueprint: Summary

In this episode, The Longevity Blueprint, host Evan Transue engages with Dr. Jeffrey Gladden, a renowned interventional cardiologist and founder of Gladden Longevity. They delve into Dr. Gladden’s personal health journey, which began in his fifties when he faced significant health challenges including exhaustion, weight gain, anxiety, and depression. Dissatisfied with traditional allopathic solutions, he transitioned into functional and integrative medicine, finding substantial improvements in his health through genetic insights and personalized treatments. 

Dr. Gladden discusses the importance of a psychospiritual foundation and introduces his methodology for longevity, emphasizing the need for an exponential approach to counteract the exponential nature of aging. He explains five critical areas: life energy, longevity, health, performance, and environment. They touch on practical measures like heart rate variability for assessing parasympathetic tone and stress resilience. 

Dr. Gladden advocates identifying with a youthful age rather than chronological age to drive proactive health and fitness behaviors. The podcast highlights the forthcoming Gladden Longevity Wingman app, which aims to democratize access to personalized health coaching. For more information, listeners are directed to Gladden Longevity’s website, podcast, and book.

The Longevity Blueprint: Topics

00:00 Welcome to the Health Detective Podcast

01:14 Introducing Dr. Jeffrey Gladden

02:30 Dr. Gladden’s Personal Health Journey

04:54 Discovering Functional Medicine

08:15 The Shift from Sick Care to Health Optimization

18:05 The Concept of Longevity

25:40 Optimizing the Nervous System

26:12 Understanding Longevity and Aging

27:05 The Importance of Genetics

27:27 Performance and Training for Longevity

28:15 The Impact of Environment on Health

28:42 The Role of Psychospiritual Health

34:41 Heart Rate Variability and Stress

38:49 Meditation and Daily Practice

43:15 Gladden Longevity Services

45:20 Final Thoughts and Advice

Where to Find Jeffrey Gladden, MD

The Longevity Blueprint, How to Live Younger, Longer, LONGEVITY, LIFE ENERGY, ENVIRONMENT, HEALTH, PERFORMANCE, GLADDEN LONGEVITY, JEFFREY GLADDEN, MD, FDN, FDNTRAINING, HEATLH DETECTIVE PODCAST, DETECTIVE EV, EVAN TRANSUE, MEDITATION, HEALTH TIPS, HEALTHY

Go to our Health Detective Podcasts for more informational and functional health-oriented podcasts like this one.

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