For sufferers with coronary heart failure and kind 2 diabetes (T2D), dapagliflozin doesn’t scale back urinary albumin-to-creatinine ratio (UACR) however does scale back some cardiovascular occasions, in accordance with a research printed on-line Nov. 27 in eClinicalMedicine.
Fumiki Yoshihara, from the Nationwide Cerebral and Cardiovascular Heart in Osaka, Japan, and colleagues carried out a multicenter, randomized trial that enrolled sufferers at 18 medical amenities in Japan to look at the results of dapagliflozin on UACR in sufferers with coronary heart failure and T2D. Eligible members had been randomly assigned to a dapagliflozin or management group in a 1:1 ratio (146 and 148 sufferers, respectively).
On the finish of the remark interval, 107 sufferers (87.7 p.c) had been taking 5 mg dapagliflozin every day. The researchers noticed no important distinction within the main consequence of adjustments in UACR from baseline after a two-year remark between the dapagliflozin and management teams. Among the many secondary finish factors, the dapagliflozin group had a bigger imply lower in left ventricular end-diastolic dimensions as one of many echocardiographic parameters. In contrast with the management group, the dapagliflozin group had the composite finish level much less usually, outlined as cardiovascular dying or hospitalization for cardiovascular occasions, hospitalization for coronary heart failure occasions, hospitalization for all causes, and a further change in prescriptions for coronary heart failure in a two-year remark.
“The outcomes obtained on the first finish level revealed no important distinction in renal dysfunction judged by UACR between the dapagliflozin and management teams, which is in distinction to earlier findings from three randomized managed trials,” the authors write.
A number of authors disclosed ties to biopharmaceutical corporations, together with AstraZeneca and Ono Prescription drugs, which partially funded the research.
Extra info:
Fumiki Yoshihara et al, DAPagliflozin for the attenuation of albuminuria in Sufferers with hEaRt failure and kind 2 diabetes (DAPPER research): a multicentre, randomised, open-label, parallel-group, commonplace treatment-controlled trial, eClinicalMedicine (2023). DOI: 10.1016/j.eclinm.2023.102334
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Dapagliflozin cuts cardiovascular occasions in sufferers with coronary heart failure, T2D (2023, December 30)
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