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The Sympathetic Spiral of Doom

December 11, 2025
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The Sympathetic Spiral of Doom: Summary

In The Sympathetic Spiral of Doom, host Evan Transue interviews Dr. Scott Sherr, a board-certified internal medicine physician specializing in health optimization medicine and hyperbaric oxygen therapy. Dr. Sherr discusses his unique background growing up with a chiropractor father, which led him to bridge conventional and alternative medicine through health optimization. 

He emphasizes the importance of foundational health, looking at metabolomic panels, organic acid testing, stool assessments, and food sensitivity tests for comprehensive health insights. A key focus is the concept of the ‘Sympathetic Spiral of Doom,’ where chronic sympathetic overdrive leads to mitochondrial dysfunction, suggesting that balancing this system is critical for overall health. 

Dr. Sherr advocates for non-pharmaceutical approaches to support the GABA system, such as kava, CBD, and specific formulations from his company, Troscriptions. He concludes that calming the nervous system is essential for long-term health optimization.

The Sympathetic Spiral of Doom: Topics

00:00 Welcome to the Health Detective Podcast

00:34 Introducing Dr. Scott Sherr

02:35 Dr. Scott’s Background and Journey

04:37 Hyperbaric Oxygen Therapy Insights

15:56 Health Optimization Medicine Explained

16:05 Metabolomics and Its Importance

24:08 Integrating Health Optimization and Functional Medicine

28:43 Lab Testing and Health Span Focus

30:23 Foundational Health Assessments

30:47 Hormone Optimization and Health Framework

31:15 Creating an Optimization Strategy

31:39 Audience Interaction and Questions

32:11 Food Sensitivity Testing

34:01 Sympathetic vs. Parasympathetic Balance

35:07 Understanding the Sympathetic Spiral of Doom

40:06 GABA System and Supplementation

55:04 Final Thoughts and Signature Question

Where to Find Dr. Scott Sherr

The Sympathetic Spiral of Doom: How Stress Quietly Destroys Health, STRESS, NERVOUS SYSTEM, PARASYMPATHETIC, SYMPATHETIC, TROSCRIPTIONS, DR SCOTT SHERR, Health Optimization Medicine and Practice, HEALTH, HEALTHY, HEALTH TIPS, FDN, FDNTRAINING, HEATLH DETECTIVE PODCAST, DETECTIVE EV, EVAN TRANSUE, SYMPATHETIC SPIRAL OF DOOM

Go to our Health Detective Podcasts for more informational and functional health-oriented podcasts like this one.

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