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Hormones, Gender, and Weight-Why Men and Women Lose Weight Differently

December 18, 2025
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Why Weight Gain Is Not Your Fault

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During reproductive years, a woman’s hormones fluctuate throughout the month. Estrogen dominance in the first half of the cycle tends to improve insulin sensitivity and energy levels. In the second half, rising progesterone can increase appetite and water retention.

These temporary changes can lead to weight fluctuations of several pounds that are not true fat gain. Recognizing this pattern prevents frustration and helps set realistic expectations.

At Valley Medical, we encourage patients to track progress in four-week cycles rather than focusing on single weigh-ins. The goal is to look at overall trends, not daily variations.

Menopause and Midlife Weight Changes

During perimenopause and menopause, declining estrogen and progesterone slow metabolism and shift fat storage toward the abdomen. Even women who maintain the same habits may notice new fat accumulation around the waist.

Research published in the Menopause Journal found that women gain an average of 1.5 to 2 kilograms during the menopausal transition, even without increased calorie intake.

At this stage, hormonal evaluation can be valuable. Some women benefit from bioidentical hormone replacement therapy (BHRT) when medically indicated. Valley Medical offers physician-supervised BHRT using pellet-based formulations that follow strict compliance and safety standards.

By balancing hormones, improving sleep, and supporting muscle maintenance, we help patients reduce midlife metabolic slowdown and improve overall well-being.

Testosterone Decline in Men

Men experience a gradual drop in testosterone beginning around age 30. This decline affects muscle mass, fat distribution, motivation, and libido. Low testosterone levels are associated with central fat accumulation and insulin resistance.

A 2024 review in Nature Reviews Endocrinology found that testosterone therapy in clinically deficient men improved body composition and insulin sensitivity when properly supervised by a licensed provider.

At Valley Medical Weight Loss, all hormone therapies are prescribed only after medical evaluation and regular lab monitoring. Not every patient is a candidate, but identifying and correcting deficiencies can help restore energy, confidence, and metabolic health.



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