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How Long Does Jeuveau Last? Comparing Results With Botox

January 5, 2026
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If you’re exploring wrinkle treatments, you have probably heard of one of the newest neuromodulators, Jeuveau. As you are weighing your options, you probably want something that looks natural and lasts. If you are considering Jeuveau, you’re probably wondering: how long does Jeuveau last? And how does it compare to Botox?

Both Jeuveau and Botox are FDA-approved treatments used to smooth wrinkles that come from expressions like frown lines between the brows or crow’s feet around the eyes. But when it comes to longevity, effectiveness, and overall value, the differences might surprise you.

Here’s a clear, science-backed guide to how long Jeuveau lasts and how it stacks up against Botox.

What Is Jeuveau?

Jeuveau is an injectable wrinkle treatment made from botulinum toxin type A, the same core ingredient found in Botox, Dysport, and other neuromodulators. Its main job is to temporarily relax the facial muscles that cause lines and wrinkles.

Unlike Botox, which is also approved for medical issues like migraines and muscle spasms, Jeuveau is made specifically for cosmetic use. It was approved by the FDA in 2019 and is sometimes referred to as “Newtox” for its similarity to Botox, but with a modern twist .

How Long Does Jeuveau Last? Comparing Results With Botox

So, How Long Does Jeuveau Last?

Standard Treatment Results

In most clinical trials, Jeuveau lasts about 3 to 4 months, which is in line with what’s typically seen with Botox. Most people notice smoother skin as early as 2–3 days after treatment, with peak results at around 1 month. After that, results gradually wear off as muscle movement returns.

The typical timeline of results after injection is:

  • After 2 to 3 days, you can expect to start feeling the stiffening of your muscles.
  • Around 7 to 14 days, you can expect to see the full effects of your injections.
  • For up to 4 months after your injection, you can expect to continue to see results.

That means you’ll likely want 3 to 4 treatments per year if this is something you plan to do continuously. You should consult your medical provider to determine what treatment plan is best for you and to make sure you are not overdoing it.

Can Jeuveau Last Longer Than Botox?

Potentially! And that’s one of the most exciting updates from the research. It is important to note that the results are only from one clinical study. However, in a clinical study comparing standard (20 units) vs. higher dose (40 units) Jeuveau, the higher dose extended the results up to 6 months for many participants without increasing side effects.

Specifically, in this study, they found, roughly 48% of patients still showed wrinkle improvement at 5 months. And almost 40% of patients still had visible effects after 6 months. This is big news for patients who want fewer appointments per year without sacrificing results. Or patients who are on a budget and want to make their money stretch without sacrificing results. It is important to remember that these results are not guaranteed because everyone is different.

Jeuveau vs. Botox: Duration of Results Summarized

Feature Jeuveau Botox
Onset of Results 2–3 days 3–4 days
Standard Duration ~3–4 months ~3–4 months
Long-Lasting Option Up to 6 months (at 40 units) Typically maxes out around 4 months
FDA Approval Year 2019 (cosmetic-only) 2002 (cosmetic + medical)
Price Per Treatment Often 20–25% less than Botox Standard market price

What Affects How Long Jeuveau Lasts?

Everybody is unique and different. This means there are so many things that can affect your results. Several factors can influence how long your Jeuveau treatment holds up:

  1. Dosage Used – Higher doses tend to last longer, as shown in the 40-unit study group.
  2. Muscle Strength – Stronger facial muscles may cause faster breakdown of the product; this is influenced by your genetics.
  3. Metabolism – Faster metabolisms can process botulinum toxin more quickly, which is also influenced by your genetics.
  4. Injection Area – Smaller areas like the brow may retain effects longer than larger areas.
  5. Consistency – Repeated treatments can lead to longer-lasting results over time.

Is Jeuveau Safe for Long-Term Use?

Yes. Clinical trials involving thousands of patients showed that Jeuveau is well-tolerated, with no serious safety issues. The most common side effects were mild and included headache, injection site bruising, or eyelid droop, which occurred in less than 2% of cases. Even at higher doses, the safety profile of Jeuveau remained consistent with no increased risk of side effects compared to standard Botox dosing.

Final Verdict: How Long Does Jeuveau Last?

Jeuveau typically lasts 3–4 months, with some users enjoying up to 6 months of smooth skin when using higher doses. That puts it on par, or even slightly ahead of Botox when it comes to longevity. Whether you’re new to wrinkle treatments or looking for a more affordable alternative to Botox, Jeuveau offers a compelling option backed by research, results, and real-world reviews.

References

Alexopoulos, A., Eberlein, B., Kompatscher, P., Läuchli, S., Reimann, K., & Staubach-Renz, P. (2022). A randomized, observer-blind, vehicle-controlled multicenter trial of an ectoine and hyaluronic acid-containing cream for atopic dermatitis in children. Journal of Dermatological Treatment, 33(7), 3300–3307. https://doi.org/10.1080/09546634.2021.2000172

Fontbonne, D., Becquart, F., & Kurzen, H. (2024). Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters. Photodermatology, Photoimmunology & Photomedicine, 40(1), 19–29. 10.1111/jocd.15893

Heinrich, U., Garbe, B., Tronnier, H., & Wiegand, C. (2007). In vivo assessment of ectoine: A randomized, vehicle-controlled clinical trial. Skin Pharmacology and Physiology, 20(4), 211–218. 10.1159/000103204

Jeong, D., Lee, J., Jeong, H., Kim, B., & Kim, Y. (2019). The skin-whitening effects of ectoine via the suppression of α-MSH-stimulated melanogenesis and the activation of antioxidant Nrf2 pathways in UVA-irradiated keratinocytes. International Journal of Molecular Sciences, 20(19), 4941. https://doi.org/10.3390/ijms20194941

Kudryavtseva, A., & Migaliev, D. (2017). Topical ectoine application in children and adults to treat inflammatory diseases associated with an impaired skin barrier: A systematic review. Clinical, Cosmetic and Investigational Dermatology, 10, 517–531.10.1007/s13555-021-00676-9

Lefort, R., Durbec, F., & Lhomme, C. (2019). Genotoxicity of visible light (400–800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens. Journal of Photochemistry and Photobiology B: Biology, 198, 111573. 10.1016/j.jphotobiol.2008.01.008

Reuter, S., Schiller, M., & Bauer, G. (2010). Ectoines as novel anti-inflammatory and tissue protective lead compounds with special focus on inflammatory bowel disease and lung inflammation. Inflammation Research, 59(12), 573–581. doi: 10.1016/j.phrs.2020.105389.

Wolnicka-Glubisz, A., Stachurska, A., & Zaleska, K. (2019). The influence of ectoine on the skin parameters damaged by a CO₂ laser. Applied Sciences, 9(23), 4998. https://doi.org/10.3390/app923499

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