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How Medication-Assisted Weight Loss Works: Benefits and Risks

July 31, 2025
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Medication-assisted weight loss simply means using prescription medicines to lose weight. These medicines are especially beneficial for people who struggle to lose weight with diet and exercise alone. The reasons could be many – hectic lifestyle, busy routines, laziness, or health conditions that prohibit patients from getting into a regular diet and exercise routine.

For them, medication-assisted therapy for weight loss comes as a ray of hope. They help them lose weight safely and effectively. But these medicines are not magic pills. They work best when combined with a healthy lifestyle.

So, even if you are thinking of using medication therapy for weight loss, you must remember that you still need to eat better, stay active, and take care of your body. Weight loss medications will just give the push you need when things get a little stuck.

What are the Different Weight Loss Medications Available in the Market

The best medication therapy for weight loss include:

  • Semaglutide – Wegovy (FDA-approved)
  • Tirzepatide – Zepbound (FDA-approved)
  • Phentermine (FDA-approved for short-term use)
  • Contrave (FDA-approved)
  • Liraglutide – Saxenda (FDA-approved)
  • Orlistat – Xenical/Alli (FDA-approved)
  • Qsymia (FDA-approved)
  • Diethylpropion (FDA-approved for short-term use)

Some medications are taken as pills, once or twice a day. Others, like Tirzepatide or Semaglutide, are weekly injections. The dose depends on your individual health conditions. Your physician usually starts with a lower dose and gradually increases it over time.

How Do These Medications Work?

Different weight loss medications help your body in different ways. Most of them don’t “burn” fat directly; instead, they change how your body responds to hunger, digestion of food, or how it stores fat. Here’s how medication therapy usually works:

  1. Reduce Hunger: Some medications send signals to your brain to make you feel full faster or to reduce your cravings. So you tend to eat less and do not feel hungry frequently. For example, Phentermine and Diethylpropion.
  2. Slow Down Digestion: Others slow down the digestion process in your body. The food stays in your stomach for a longer period of time and you naturally feel fuller for longer. The result? You do not feel the urge of snacking between the meals. Some medicines that work this way include GLP-1 medications like Semaglutide (Wegovy) and Tirzepatide (Zepbound).
  3. Regulate Blood Sugar: Some medicines, like Ozempic, help control blood sugar. When blood sugar is stable, it becomes easier to lose weight and manage hunger.
  4. Block Fat Absorption: A few medicines stop your body from absorbing all the fat from the food you eat. This means fewer calories are stored. For example, Orlistat.
  5. Combination Medicines: Some weight loss pills, like Contrave, combine two different actions — one to control hunger and the other to control emotional eating due to stress or mood swings.

Who Can Use These Medications?

Medication-assisted therapy isn’t for everyone. Weight loss consultants usually recommend these medicines to adults who:

  • Have a BMI of 30 or higher (classified as obese), or
  • Have a BMI of 27 or higher and also have a health issue like type 2 diabetes, high blood pressure, or sleep apnea

Before starting any weight loss medication therapy, your doctor will look at your health history, current medications, and overall goals. They’ll decide if this kind of treatment is right for you — and which option will work best.

Benefits of Medication-Assisted Therapy for Weight Loss

Now let’s talk about why people choose this method and what makes it so effective.

More Weight Loss Than Diet Alone

Many studies have shown that people using these medications — along with healthy eating and movement — lose more weight than those who try without them.

For example, people using Tirzepatide have lost 15% to 22% of their body weight over about a year. That’s huge.

Better Health

Weight loss helps your body in a lot of ways. It lowers your blood pressure, improves blood sugar levels, and reduces your risk of heart disease. In fact, some medications were originally created for people with diabetes — and then doctors noticed they helped with weight too.

More Motivation

Seeing results can boost your confidence. When the weight starts to come off, it often becomes easier to stick with good habits and keep going.

Long-Term Support

Some medications can be taken long-term to help prevent the weight from coming back — especially when used with the right guidance and check-ins.

Risks and Side Effects

Just like any medication, weight loss drugs can come with side effects. Some common ones include:

  • Nausea
  • Diarrhea or constipation
  • Stomach aches or bloating
  • Headaches
  • Tiredness or dizziness

These symptoms usually go away over time. But in rare cases, some more serious side effects can happen, like:

  • Pancreatitis
  • Gallbladder problems
  • Increased heart rate
  • Allergic reactions

Some medications are not recommended if you have a history of certain health conditions like thyroid cancer or liver disease. That’s why it’s important to take them only under the care of a board-certified obesity medicine physician like Dr. Mona Lala.

Is Medication-Assisted Therapy Right for You?

If you’ve tried everything and are still not able to lose weight or are unable to lose weight due to health-related issues, medication-assisted weight loss therapy can prove to be the best non-surgical way to lose weight.

Talk to a board-certified weight loss doctor, like Dr. Mona Lala, to explore your options, get answers to all the questions you may have, and get a safe and effective plan that’s tailored to your needs.

Book a free consultation and take the first step toward a healthier you.



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